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In such cases, our bodies need antioxidants from external sources

These effects are mediated through entirely distinct receptor populations , MC1R on peripheral melanocytes drives melanogenesis, while MC3R/MC4R on hypothalamic PVN and limbic neurons drives pro-erectile oxytocinergic and dopaminergic signalling

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Highlights glutathione among several agents that can shift melanogenesis toward pheomelanin synthesis, offering insight into alternative hyperpigmentation therapies