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Abbreviations ACI: Autologous chondrocyte implantation Ad: Adenoviral AAV: Adeno-associated virus AD-MSCs: Adipose-derived mesenchymal stem cells BM-MSCs: Bone marrow-derived MSCs BMP: Bone morphogenic protein CaAb: Cartilage-targeted single-chain human antibody fragment ECM: Extracellular matrix ERK: Extracellular signal-regulated kinase HIF-1: Hypoxia inducible factor-1 IGF: Insulin-like growth factor IGF1R: Insulin-like growth factor 1 receptor IRS: Insulin receptor-substrate IL: Interleukin KGN: Kartogenin MACI: Matrix-induced ACI MAPK: Mitogen-activated protein kinase MMP: Matrix metalloproteinases MSCs: Mesenchymal stem cells mTOR: Mammalian target of rapamycin NF-B: Nuclear factor kappa light chain enhancer of activated B cells NPs: Nanoparticles OA: Osteoarthritis PI3K: Phosphatidylinositol 3-kinase SF: Synovial fluid OPF: Oligo (polyethylene glycol) fumarate TGF-1: Transforming growth factor-1 TNF-: Tumor necrosis factor alpha Xp-HB-IGF-1: Heparin bound to IGF-1 RA: Rheumatoid arthritis FOXO: Forkhead-box class O SA--gal: Senescence-associated -galactosidase References Trippel S, et al

I started in February of 24 after the scale at the doctors office clocked in at 265 pounds and my A1C was in the 9s

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Focus on water, protein and vitamin-rich foods, and always follow the personal aftercare advice from your CoLaz clinician

Major medical and endocrine societies recommend stopping GLP-1 medications before pregnancy and using other diabetes or weight-management strategies that are known to be safer in pregnancy when needed