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253 These limitations stem from the pleiotropic nature of upstream signaling pathways and their network-level crosstalk, which diminishes the efficacy of monotherapeutic approaches targeting cardiac remodeling

10.1111/cen.13003 Clin Endocrinol (Oxf)

Source: NIH Office of Dietary Supplements [1]

These renal benefits independently contribute to cardiovascular risk reduction, though SGLT2 inhibitors remain foundational therapy for heart failure and CKD when appropriate

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