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Nat Rev Endocrinol 18 , 391 (2022)
Aging (Reduced Synthesis Capacity) As you age, production of glutathione declines due to: Reduced activity of gamma-glutamylcysteine ligase (GCL) , the rate-limiting enzyme in glutathione synthesis Decreased cellular energy (ATP) to fuel glutathione recycling Lower levels of precursor amino acids (especially cysteine and glycine) Studies show glutathione levels drop 10-15% per decade after age 40 [3]
Unlike many other vitamins, it is naturally found primarily in animal-based foods (meat, eggs, dairy, shellfish)
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