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The most common cause of Vitamin B12 deficiency is a lack of intrinsic factor, a protein the stomach produces that is essential for B12 absorption

doi: 10.1016/0098-2997(93)90002-U 41

5-Amino-1MQ instead removes a drain on that route: by inhibiting NNMT it prevents nicotinamide from being methylated to 1-methylnicotinamide, leaving it available for NAMPT and the salvage pathway, and simultaneously spares the S-adenosyl-L-methionine that the methylation would have consumed