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This disbalance results in the accumulation of the toxic products of apoptosis in the brain leading to behavioral abnormalities [158, 243]
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doi: 10.1111/j.1745-4530.2010.00577.x 16
Likewise, restraint stress rapidly modulated KP enzyme expression in rats, with amygdala IDO increasing within 1 h, amygdala KMO and kynureninase rising by 4 h, hippocampal TDO decreasing within 4 h, hypothalamic TDO upregulated at 4 h, and medial prefrontal cortex kynureninase reduced shortly after stress with effects lasting at least 24 h [70]
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