tirzepatide surpass trials SURPASS-2 (NEJM 2021) was the definitive head-to-head: vs semaglutide 1.0 mg (the maximum approved T2DM dose) in 1,879 patients with type 2 diabetes. All three tirzepatide doses produced superior HbA1c reductions Full article: An update on

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For background on retatrutide as a research-stage treatment, see Retatrutide Research Peptide

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A potential downside to step therapy is that by requiring you to try less expensive drugs, it may disrupt your care, especially if your healthcare provider recommends a medication like Zepbound that isnt the insurers preferred treatment