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Lund AM, et al
Lopes, NMD, Lens, HHM, da Silva Brito, WA, Bianchi, JK, Marinello, PC, Cecchini, R., Cecchini, AL
They do not modulate incretin signaling
Consistent with these findings, left ventricular mass and heart weight were lower in hypertensive semaglutide-treated Glp1r VSM+/+ mice but not in Glp1r VSM/ mice (Supplemental Figure 3, D and E)
Clinical trials have shown it produces somewhat larger average weight loss than semaglutide alone, which may be relevant for adults over 50 who have more metabolic resistance to overcome
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