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Despite these findings suggesting a minimal direct influence of depression on glycemic control, this condition may still significantly heighten the risk of severe complications in diabetes [14], emphasizing the necessity for comprehensive management approaches that address both psychological and physiological aspects of diabetes care
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Therefore, to fully evaluate the role of elastase under these conditions, further studies using an alternative pseudotyped virus system or authentic virus infection in these physiologically relevant cells are warranted
A recent post-hoc analysis of SURPASS-3 (NCT03882970) in adults with T2DM reported decreases in fat mass and muscle fat infiltration (MFI) accompanying weight loss [65], suggesting potential improvements in muscle quality that may be especially promising for older adults
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