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Adejumo P, Thangaraj P, Dhingra L, Aminorroaya A, Zhou X, Brandt C, Xu H, Krumholz H , Khera R

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Avoid repeated freezethaw cycles, and do not store peptides in frostfree freezers, as temperature fluctuations during defrost cycles may impact stability

10 Synthesis and future outlook: rediscovering dormant biology in the era of peptide engineering The cumulative evidence reviewed across metabolic, appetite-regulatory, bonemusclefat, neuroendocrine, and immunemetabolic peptide systems support a unifying conclusion: the apparent scarcity of transformative peptide therapeutics is not a consequence of limited biological opportunity, but rather of historical constraints in pharmacologic execution, translational strategy, and conceptual framing