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Vladimir Khavinson, a gerontologist, and his team

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Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription: Synergistic activation of Nrf2 by CBP

Caspase-4/5/11 can also activate the NLRP3 inflammasome, which subsequently activates caspase-1, resulting in the production and release of IL-1 and IL-18 (Sahoo et al., 2023)

Yeast two-hybrid (Y2H) assay Full-length sequences of ShD14, ShHTL1, ShHTL3, ShHTL4, ShHTL7, and AtHTL were cloned into the pGBKT7 vector as bait (Clontech), and the coding regions of ShMAX2 and AtMAX2 were cloned into the pGADT7 vector as prey (Clontech)