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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology
They discovered that the binding of a peptide mimicking the MDM4 C-terminus tail to MDM2 impairs MDM2-mediated ubiquitination of p53 and promotes p53-dependent transcription and oncosuppressive activities [57]
Others continue losing beyond twelve months toward more aggressive targets
No long-term safety data beyond 6 months
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