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Most GLP-1R agonists are safe to use
Based on 125,474 adults with overweight or obesity who newly initiated GLP-1based injectables between January 1, 2018 and December 31, 2023
They are designed to interact with the body's melanocortin system, a sprawling network of signaling pathways that governs a surprising number of physiological processes
However, not all MMNST cases exhibit PRKAR1A loss, indicating potential alternative oncogenic mechanisms, such as aberrations in the MAPK or mTOR pathways (6)
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