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The entero-endocrine-osseous axis involves gastrointestinal substrates for DPP-4, including glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptides 1 (GLP-1) and 2 (GLP-2)

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Semaglutide produces clinically significant improvements in glycemic control through multiple complementary mechanisms

While additional research is needed, it is believed that the role Rybelsus plays in managing blood sugar levels in patients with type 2 diabetes may play a part