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Due to abnormal intracranial PLP transport in patients with TNSALP mutations, there is insufficient neurotransmitter synthesis in the brain, which eventually contributes to PL-dependent seizures, usually preceding the onset of skeletal changes [41, 49,50,51,52]
Nourishes the scalp
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As noted above, Trxs are responsible for reducing Prx back to their reduced, oxidant-scavenging state, while thioredoxin reductases (TrxRDs) keep the reduced state of Trxs using NAPDH reducing equivalents, as depicted in Figure 2
Figure 1 : Under physiologic conditions, glutamic acid loses a hydrogen ion (H+) to yield glutamate
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