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Keep in mind: These factors may contribute to discomfort, but they are not the only possible explanation for symptoms

Palasz E, Wysocka A, Gasiorowska A, Chalimoniuk M, Niewiadomski W, Niewiadomska G

Clinical course of nonalcoholic fatty liver disease: an assessment of severity, progression, and outcomes

Combination therapy with SGLT2is + GLP-1RAs can address multiple components of the ominous octet (insulin and glucagon secretion, hepatic glucose production, gastrointestinal incretin defect, appetite and weight loss, and muscle and hepatic insulin sensitivity), improve cardiovascular risk, and prevent diabetic nephropathy and should therefore be considered as an option during the early treatment stages of patients with T2DM