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Most patients naturally eat 20-30% fewer calories without counting

They used population pharmacokinetic/pharmacodynamic (PK/PD) modeling to analyze tesofensine and its metabolite, as well as cognitive assessment scale data from 62 mild AD patients in placebo-controlled studies

Beyond these clinically recognized effects, sustained caloric restriction during pharmacological weight reduction represents a chronic constraint on systemic energy flux

Acknowledgements The work was partially supported by the Research Council of Norway through its Centres of Excellence scheme, project number 332727, and grant 274993 (J.T.A., J.N., and S.B.), grant 287927 (J.T.A., K.H.A., and F.R.J.), and grant 285136 (J.T.A.)

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