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Hyperglycemic conditions and the resultant metabolic disorder primarily disrupt autophagy by blocking autophagic flux and compromising lysosomal function, ultimately leading to stagnation of the autophagy pathway (146, 147)

This reduction was prevented by the supplementation of carnitine

Bioinformatic analysis The identification of single nucleotide polymorphisms (SNPs) was performed using SAMtools mpileup ( GSH1 and GSH2 promoter regions, whereas putative binding sites for transcriptional factors near promoter sequences were identified with Yeastract ( GSH1 and GSH2 modelling to compare with those obtained from S.cerevisiae EC1118 (reference templates)

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It activates 1,942 genes (including 47 DNA repair genes and 14 antioxidant genes) and suppresses 762 genes involved in inflammation and fibrosis