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Mutations of ADNP and SHANK3 impair the binding of ADNP and Shank3 to actin leading to autistic behaviors, anxiety, and depression due to synaptic dysfunctions [283, 293]
Glutathione plays a crucial role in supporting liver function by helping to neutralize and eliminate these toxins
This interaction is mechanistically consistent with the observation that the protective effect of high broccoli intake against colorectal adenomas was exclusively evident in individuals with the GSTM1-null genotype, likely due to prolonged tissue exposure to bioactive ITCs (60)
Key Takeaway: Acetaldehyde is the toxic byproduct of alcohol metabolism
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