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Physicians should avoid prescribing it to: Patients with a history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN2). Individuals with severe gastrointestinal conditions, such as gastroparesis. Patients with a known allergy to GLP-1 receptor agonists. Pregnant or breastfeeding women, unless approved by a physician
Those effects are powerful while the drug is active, but stopping the drug allows hunger hormones, neural reward pathways, and energy expenditure patterns to drift back toward their previous states
QZ: Methodology, Writing review and editing
GLP-1 and its derived peptides mediate pain relief through direct TRPV1 inhibition without affecting thermoregulation
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