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Moreover, we discuss cutting-edge tools that are revolutionizing resistance research, including single-cell and spatial multiomic profiling, patient-derived tumor organoid and xenograft (PDO/PDX) models, and artificial intelligence (AI)-powered predictive analytics

doi: 10.1016/j.pnpbp.2010.07.030 61 Cortes RiveraMMastronardiCSilva-AldanaCArcos-BurgosMLidburyB

89 Berberine Berberine is a bioactive alkaloid found in several medicinal plants including goldenseal and phellodendron

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Secondary metabolic markers include fasting glucose, insulin sensitivity via HOMA-IR or glucose tolerance testing, body composition changes (DEXA scan or MRI for fat mass and lean mass distribution), mitochondrial respiration capacity via Seahorse analyzer, and serum markers like HbA1c for long-term glucose control