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Tirzepatide for metabolic dysfunctionassociated steatohepatitis with liver fibrosis

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Trulicity ingredients Active ingredient: dulaglutide Inactive ingredients: citric acid anhydrous, mannitol, polysorbate 80, trisodium citrate dihydrate, in water for injection

The study showed that the renal extraction of GLP-1, natriuretic effect of GLP-1 and change of plasma concentrations of ANG II was abolished by the GLP-1 receptor antagonist Exendin 939 (Ex 939), suggesting that GLP-1-induced natriuresis is dependent on GLP-1 receptor activation 38