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The agonist TUG469 ameliorates neurodegeneration and motor impairment both in vitro and in animal models of PD by downregulating the NLR Family Pyrin Domain Containing 3 (NLRP3) inflammasome [66]
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Human clinical evidence tying these mechanisms to bodybuilding outcomes, meaning measurable muscle mass, strength, or body-composition change, is limited for most compounds covered here
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