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Second, chemical modifications (fatty acid conjugation, unnatural amino acids, DPP-IV-resistant substitutions) are essential for converting short-acting natural peptides into therapeutically useful molecules
Nrf2 translocates to the nucleus and interacts with the antioxidant response element (ARE) of target genes, resulting in expression of antioxidant genes, which induces an antioxidant response shown to be beneficial for several human conditions 48
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GLP-1RA Use Patterns and Discontinuation Rates The study included 201,136 incident sulfonylurea users and 132,551 incident GLP-1RA users, with a median follow-up of three years
5.3 Legitimate Interests (Art
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