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Functional Mobility: Stair climb performance improved significantly (1.2 seconds faster) only when exercise was included
Exceptions are the ER lumen, the vacuole and the apoplast, where GR, to regenerate GSH from GSSG, is absent (Noctor et al
For example, Ceriello et al
That said, people should be careful not to overstate what this means
GLP-1 Receptor Pathway - Reduces hunger drive centrally (hypothalamus, brainstem) - Decreases the reward value of food (mesolimbic system) - Enhances glucose-dependent insulin secretion - Slows gastric emptying Amylin Receptor Pathway - Induces satiety through the area postrema and NTS - Activates POMC neurons (pro-satiety) and suppresses NPY/AgRP neurons (pro-hunger) in the arcuate nucleus - Additional gastric emptying delay through distinct neural circuits - Suppresses post-prandial glucagon secretion - May contribute to leptin resensitization The combination of these two pathways produces what researchers describe as broader modulation of neuroendocrine appetite control meaning amycretin hits more of the biological "switches" that drive eating behavior than a GLP-1-only drug can reach
