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Additional findings Beyond weight loss, the Phase 2 trial revealed several additional benefits

Grading the strength of evidence The strength of evidence is very low limited mainly by the precision of estimates, risk of bias and potential publication bias of the included studies (Electronic Supplementary Table 3)

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Despite these differences, the respiratory exchange ratio the ratio of VCO 2 produced to VO 2 consumed remained unchanged (Supplemental Figure 7, J and K), indicating no substantial differences in the metabolic utilization of carbohydrates and fats between the TeNT mice and the controls

However, many patients find that injecting before or during a light meal helps them tolerate initial nausea better during the first few weeks of therapy