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Although brain infarction volume reduction did not reach statistical significance, motor performance in the rotarod test significantly recovered in DSIP-treated animals compared to vehicle controls confirming a functionally relevant neuroprotective effect at the behavioural level and establishing intranasal delivery as a viable route for CNS DSIP research

Compared to ipamorelin, which is considered the most selective GHRP, GHRP-2 achieves greater absolute GH output but at the cost of moderate effects on the ACTH-cortisol axis and prolactin secretion that ipamorelin avoids entirely

Gao PY, Ou YN, Wang HF, Wang ZB, Fu Y, He XY, Ma YH, Feng JF, Cheng W, Tan L, Yu JT

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Additional investigations by Bonfiglio et al