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C94Y Diabetes 62 , 15051511 (2013)
Protective effects of tanshinone IIA on myocardial ischemia reperfusion injury by reducing oxidative stress, HMGB1 expression, and inflammatory reaction
a 2006 clinical trial found CJC-1295 alone produced 1.5- to 3-fold IGF-1 increases lasting 9-11 days after a single dose Administration: Subcutaneous injection Typical dosing range: 100-300 mcg of each peptide per injection, once daily (typically before sleep on an empty stomach) Cycle length: 12-24 weeks
As an outlook, preclinical encapsulation strategies are being explored to protect peptides from digestion and prolong systemic exposure, potentially improving oral bioavailability (Reference Zhou, Jiang and Zhang7)
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