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Table 3 summarizes the pooled data on the gastrointestinal adverse reactions observed in the SURPASS-1 to SURPASS-5 studies for T2D therapy in comparison to placebo ( Table 3 Comparable to observations during treatment with GLP-1RA, symptom-free elevations of pancreatic enzyme concentrations for amylase and lipase were seen in the above-mentioned SURPASS studies ( Further adverse events observed with tirzepatide treatment included sinus tachycardia associated with a concomitant increase from baseline in heart rate of 15 beats per minute (4.6%10.0% vs

& Millis, K

Synthetic fragment of Thymosin 4

9.4 Enzymatic deficiencies that are not defects

P-interaction = 0.042) may reflect sex differences in colorectal cancer biology or differential metabolic response to GLP-1 RA therapy