In addition, as mentioned previously that MMP-2 was significantly increased in leiomyoma cells, Curcumae rhizoma was also reported to inhibit the expression of MMP-2 which could also contribute to its use in the treatment of UF ( Curcumae rhizoma was also able to induce apoptosis by decreasing the level of BCL-2 and at the same time inhibit the phosphorylation of the AKT/NF-B pathway ( When both of these herbs are used together (known as CRSR, CR:SR = 1:1) in the treatment of UF, the uterine mass was found to be decreased significantly with a significantly lowered progesterone and estradiol level
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ACTIVE INGREDIENTS: GHK-CU (Copper Peptide), Ubiquinone (CoQ10), Thioctic (R-lipoic) Acid, Zea Mays, Phenyl-N-Butyl Nitrone (Spin Trap), Acetyl Carnitine (L), Adenine, Hydrolyzed Rice (Peptide) Protein, Malus Domestica (Apple) Fruit Cell Culture Extract, Rubus Villosus (Blackberry) Fruit Extract, Phyllanthus Emblica (Amla) Fruit Extract
Protocol BPC-157 : 5001000 mcg daily with a meal
These in vitro results demonstrated that H2O2 induces Leydig cell senescence, accompanied by FOXO4 nuclear translocation and activation of senescence pathways