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For people managing type 2 diabetes with these compounds under medical supervision, individual targets may differ based on clinical history and complication risk
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A 36 mg dose of the drug, taken once per day without food and water restrictions, reduced weight by an average of 12.4%, compared to 0.9% for participants in the placebo group
In this review, examples will be discussed how experimental conditions (dose, solvent, etc.), the experimental system (species, strain, and substrain in vivo, cell type, and in vitro conditions), and also adaptive responses and off-target effects of genetic manipulations and chemical interventions, can impact the mechanisms of cell death
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