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It can lead to a seemingly sudden departure of hair
Using the human HEK293 fibroblast cell line transfected with ABCG2 (HEK293-ABCG2), they found that hispidulin effectively blocks ABCG2-mediated MXT efflux, implying that hispidulin could be used in combination with chemotherapeutic medicines to sensitize chemoresistant cancer cells that overexpress ABCG2 [66]
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Consequently, the origin of lipid metabolites in vivo studies may lack clarity, necessitating further exploration into metabolite identification, molecular mechanisms elucidation, and technological advancements to evaluate metabolic heterogeneity
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