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It means there is no real evidence for their benefits there is no information regarding their safety, and the long-term effects of the substances are unknown
Many of these patients have nerve pathology, regenerative medicine candidacy, or surgical options that have not yet been properly evaluated
Since their initial approval in the early 2000 s, the pharmacotherapy of GLP-1 RAs has been well recognized not only for achieving glycemic targets but also for their effectiveness in promoting satiety and weight loss, as well as their association with reductions in cardiovascular risk and all-cause mortality
Hansen, R
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