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Answer: The most common side effects of amylin analogs are gastrointestinal, including nausea, reduced appetite, and occasional vomiting or constipation, and they are usually mild, dose-related, and managed by slow titration
In male mice, oral l-valine stimulated GLP-1 secretion similar to orally given glucose, demonstrating that l-valine is likewise a powerful stimulator of GLP-1 release in mice in vivo
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Its extreme short half-life (minutes) means intranasal or oral routes without modification are ineffective due to rapid degradation
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