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In the Con-DSS group, strong positive signals were observed in the cytoplasm of epithelial cells and infiltrated immune cells in the colon and rectum on the 5th day of DSS administration (Fig
Depletion of intracellular glutathione contributes to JNK-mediated death receptor 5 upregulation and apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me)
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Partially with DHT blockers and minoxidil
The second is dose and route translation : even where an effect is real in a mouse, the human-equivalent dose is not a simple body-weight scaling, and as the route section above stressed there is no human bioavailability figure to anchor an oral-versus-injected comparison
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