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They cannot pass through a cell's fatty membrane, so they bind to receptors on the cell surface to send their signals inward
Nonetheless, extant clinical trials and vast research in animal models indicate a positive safety profile [17]
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Due to its plasma half-life of approximately 3.8-6.9 hours, a twice-daily (BID) dosing schedule may be used to provide more consistent and sustained inhibition of NNMT throughout the day, potentially maximizing its metabolic effects
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