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[1] [2] During this period, you may notice: Rising blood glucose levels as the medication's glucose-lowering effect wanes Increased appetite as the appetite-suppressing properties diminish Potential weight regain if dietary habits have not been modified Return of previous symptoms such as increased thirst or frequent urination The speed and severity of these changes vary considerably between individuals and depend on factors including your baseline diabetes control, concurrent medications, diet, physical activity levels, and the duration of Rybelsus treatment