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GLP-1 receptor agonists, including tirzepatide, are thought to exert neuroprotective effects through the modulation of neuroinflammation, the hypothalamic-pituitary-adrenal (HPA) axis, and neurotransmitter pathways, which play key roles in mood regulation and stress response ( The study has several strengths, including the use of a large, real-world database from the TriNetX network, which enhances the generalizability of our findings

To view a copy of this licence, visit About this article Cite this article Abdelwahab, O.A., Abdelaziz, A., Diab, S