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ACK1 further phosphorylates AR at Y267, sustaining the oncogenic activity of acK609-AR and promoting the growth of castration-resistant prostate cancer (CRPC)
TB-500 is a synthetic version of the naturally occurring peptide LKKTETQ
In: Shils ME, Olson JA, Shike M, Ross AC,eds
Unlike leucine and arginine, SAMTOR directly binds and activates GATOR1 but does not inhibit GATOR2, which is upstream of GATOR1 in this pathway
This is why patients with neurological involvement are often maintained on a more frequent schedule (every 2 months rather than every 3 months)
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