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Despite multiple metabolic processes modulate susceptibility to ferroptosis, iron metabolism remains the central mediator of ferroptosis (189)
Statistical analysis Statistical analysis was performed using Graphpad Prism v10.2.1
In this study, the cGAS-STING-ferroptosis axis was first confirmed in chondrocytes in RA, rather than in macrophages or tumor cells as previously reported [57, 58]
Some patients may respond to the starting dose
Some continue medication long-term, others transition off gradually while monitoring weight, and some use intermittent treatment if weight starts creeping back up
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