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Other GU effects reported in 0.1% to 1% of patients during clinical trials of topiramate as monotherapy or adjunct therapy for epilepsy included urinary retention, renal pain, albuminuria, polyuria, and oliguria

Some researchers who experience inadequate appetite suppression with semaglutide alone or who are not losing weight on GLP-1 monotherapy find that the amylin pathway provides the additional appetite regulation they need

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Both of these fall within the C11-C24 feeding window