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GGT inhibitor amlodipine, through its anti-inflammatory effect, suppresses p38 MAPK-triggered pro-inflammatory signaling, decreasing expression of TNF- and other downstream targets while upregulating expression of the transcription factor Nrf2 and the antioxidant protein heme oxygenase-1 (164)
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This is due to a rapid depletion in the adrenal stores of the vitamin
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Inagi et al., 2010)
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