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You may notice increased appetite and reduced feeling of fullness as the drug's action on GLP-1 receptors in the brain and gastrointestinal tract diminishes

And high patient out-of-pocket costs owing to lack of insurance coverage continues to be a substantial obstacle, limiting initial uptake and leading to discontinuation for some who do start

Central Nervous System Effects: GLP-1 receptors are also found in the central nervous system, particularly in the brain regions associated with appetite and food intake