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While most antioxidants work in specific areas (vitamin C protects watery environments, vitamin E guards fatty tissues), glutathione works everywhere in your body
Using 35S-labelled cysteine and methionine as tracers, it was found that the essential difference between the 'resistant' and 'sensitive' lines was that the 'resistant' lines had higher steady-state rates of GSH synthesis than the 'sensitive' lines
This not only reduces the burden of travel but also makes it easier to stay consistent with treatment
Therefore, therapeutic strategies that target the distinct mitochondrial metabolic features of CSCs and DTPs, such as disrupting the AMPKOXPHOS axis, inhibiting mitophagy, or decoupling metabolic signaling from DNA repair, represent a promising approach to overcoming chemoresistance in CRC
Metabolism: clinical and experimental
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