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In the presence of peroxides, the selenolate form of GPX4 is oxidized to selenic acid, which is regenerated to its active form by two molecules of reduced GSH, converting lipid hydroperoxides into non-toxic lipid alcohols and generating oxidized GSH (16,9294)
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Rats exposed to chronic stress show a low dopamine (DA) output in the nucleus accumbens shell (NAcS) and do not acquire an appetitive behavior sustained by the earning of vanilla sugar (VS) made contingent on the choice of one of the two divergent arms of a Y-maze (VS-sustained appetitive behavior, VAB), while control rats consistently do