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The cytotoxicity of vitamin C can be explained by vitamin C-mediated increase in the levels of hydrogen peroxide and the formation of hydroxyl radicals via the Fe-Fenton reaction

PMID: 11754102 Callewaert BL, Loeys BL, Ficcadenti A, Vermeer S, Landgren M, Kroes HY, Yaron Y, Pope M, Foulds N, Boute O, Galn F, Kingston H, Van der Aa N, Salcedo I, Swinkels ME, Wallgren-Pettersson C, Gabrielli O, De Backer J, Coucke PJ, De Paepe AM

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Mechanisms differ, and they can be synergistic