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The most vulnerable people went first

Patient-specific risk factors include: Personal or family history of nephrolithiasis : Individuals with prior kidney stones have a recurrence rate of approximately 50% within 510 years, making this the strongest predictor of future stone formation

This article does not provide specific storage temperatures, in-use shelf lives, or handling instructions for retatrutide powder, as no product-specific, MHRA-approved guidance is publicly available and any such advice outside the sponsor's documentation would be speculative and potentially unsafe

Nature Medicine (2025)