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At week 26, the reduction in waist circumferences were significantly greater with oral semaglutide than with empagliflozin [27]
On the positive side, selective GLP-1 receptor agonism avoids the glucagon receptor-mediated hepatic glucose output and potential ketogenic effects that complicate dual agonist approaches
Earlier work from the same research group identified cost and coverage limitations as the dominant reason patients stopped in the first place
Summary of Product Characteristics (Victoza)
Waist circumference decreases by 4 to 8 inches on average
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