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In one study, the CD44 rs1467558 polymorphism was reported to be significantly associated with an ALT rise in independent cohorts of patients given a therapeutic dose of 4 g/day of paracetamol over 7 days [42]
JAMA 298:194206 Phung OJ, Scholle JM, Talwar M, Coleman CI (2010) Effect of noninsulin antidiabetic drugs added to metformin therapy on glycemic control, weight gain, and hypoglycemia in type 2 diabetes
GLP-1s work like finding that perfect volume setting: just enough to keep you company without drowning out your thoughts
Even though none of these theories have been mechanistically proven during a hypoglycemic event, an increase in GLP-1 could be associated with hepatic autophagy