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Staresinic et al., 2003

Regulatory status : CagriSema has an NDA filed

53 As the dimers enter the nucleus they are further regulated by tissue-specific co-trans-activation factors, and then, next to estrogen response elements (ERE) to stimulate gene expression

2.5 Dry eye disease (DED) One of the main causes of eye care visits is dry eye disease (DED), a complex ailment of the ocular surface and tear film that causes pain, visual disturbances, tear film instability, and possible ocular surface damage [34,35,36]

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